Charitible Giving/Smart Philanthropy:
www.guidestar.org  and  www.charitywatch.org will help you find the best non-profit to give to, and help you focus on what percentage of your gift will untimately reach the people you want to benefit.

Donor-Advised Funds:
Donor-advised funds are similar to a charitable foundation, except that they are much easier to set up and maintain. These funds, generally run by community foundations or financial services organizations, allow you to donate cash or securities today but give the money to the end-recipient charities over Time. 
Here are a couple to check out:
www.schwabcharitable.org/scf   (Schwab Charitable Fund)
www.givingback.org  (The Giving Back Fund)